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Work Smarter Using Isoschizomers and Neoschizomers
By Kyle Hooper, Ph.D.
Promega Corporation
New restriction endonucleases are continually being isolated from bacteria
and studied for their ability to manipulate DNA. Frequently, newly
discovered enzymes are found to cut DNA in patterns identical to those of
previously isolated enzymes but have performance advantages that the
existing enzymes lack, including cost and/or efficiency benefits. This
article explores the benefits of isoschizomers and neoschizomers in the
manipulation of DNA by comparing activities of recently isolated enzymes
with those of their classic or previously isolated counterparts.
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