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Protein Kinases as Drug Targets in
High-Throughput Systems
Said Goueli, Ph.D.
Promega Corporation
There are an estimated 2,000 kinases and 500 phophatases in the human genome, and
almost one-third of all proteins in a cell can be phosphorylated. The completion of
sequencing of the human genome and other genomes may lead to the discovery of additional
kinases and phosphatases, many of which could be implicated in the regulation of cell
growth. With these discoveries comes the need for novel reagents and specific assays to
identify potential gene products and to characterize these enzymes and their functions in
the cell.
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