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Cleaved PARP as a Marker for Apoptosis in Tissue Sections
By Michiel Knaapen, Ph.D., Martine De Bie, B.S. Johannes
Muhring, B.S., and Mark Kockx, M.D., Ph.D.
Department of Pathology, AZ-Middleheim, and Applied Cardiovascular Morphology, Antwerp,
Belgium
The TUNEL assay, while popular for the detection of apoptotic cells, can yield highly
variable results when used for apoptosis detection on research samples from various
disease states. Use of a second, more specific marker of apoptosis, such as Promega's
Anti-PARP p85 Fragment pAb, significantly enhances identification of apoptosis in
pathology research specimens.
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