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U0126:
A Novel, Selective and Potent Inhibitor of MAP Kinase Kinase (MEK)
By Said A. Goueli, Kevin Hsiao,
Tingyun Lu and Dan Simpson
Promega Corporation
Mitogen-activated protein kinases (MAPKs) are
involved in a number of cell signaling pathways. These enzymes are activated by dual
phosphorylation of threonine and tyrosine residues in response to a multitude of
extracellular stimuli. Activation of MAPKs are mediated by another set of enzymes referred
to as MAPK kinases or MEKs. In this article, we introduce MEK Inhibitor U0126, a compound
that exhibits potent MEK inhibitor activity both in vitro and in vivo.
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