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DeadEndTM Colorimetric Apoptosis Detection System: Applications
in Pathology
By Martha O'Brien and Angela
Okragly, Promega Corporation; Tom Warner and Ron Kalil, University of Wisconsin Medical
School; and Guus Wolswijk, Netherlands Institute for Brain Research, Amsterdam, The
Netherlands
The genetic, molecular and morphological
aspects of apoptosis currently are under intensive study because of the important role
apoptosis has in development and homeostasis, as well as in several disease states.
Promega's DeadEndTM Colorimetric Apoptosis Detection System labels
fragmented DNA, one of the biochemical hallmarks of apoptosis. This colorimetric system is
ideal for labeling apoptotic nuclei in tissue sections and cultured cells, while allowing
for concurrent morphological assessment. In this report, the DeadEndTM
Apoptosis System is demonstrated in situ using cellular and animal models of
apoptosis and in multiple pathology tissue sections.
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