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Anti-ACTIVETM
Antibody for Specific Detection of Phosphorylated CaM KII Protein Kinase
By Said A. Goueli, Martha O'Brien
and Kevin Hsiao
Promega Corporation
The multifunctional
calcium/calmodulin-dependent protein kinase, also known as CaM kinase II (CaM KII), is
present in high concentration in brain tissue and may play a role in mediating cellular
functions. Many long-term potentiation phenomena involved in learning have been attributed
to the autophosphorylated form of the enzyme, as it remains active even in the absence of
calcium. Promega's Anti-ACTIVETM CaM KII polyclonal antibody (T286) is specific for the phosphorylated form of the
enzyme and can be used in studies requiring highly sensitive detection.
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