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Signal Integration and Activation of MAP, JNK
and p38 Kinase Pathways in 293 Cells
By Melanie H. Cobb, Department of Pharmacology,
University of Texas Southwestern Medical Center, and Erik M. Schaefer, Promega
Corporation
The need to study coordinated signaling of kinase cascades in response to a variety
of extracellular stimuli is critical to advances in fundamental cell biology and disease
mechanisms. The availability of highly selective phosphorylation-specific antibodies that
selectively target the active form of the ERK/MAP enzymes provides a powerful new approach
to unraveling the regulation of these pathways.
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