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Detection of JNK, p38 and MAPK Enzyme
Activation Using Anti-Dual-Phosphopeptide Antibodies: Coordinated Signaling of the
Extracellular Signal-Regulated Protein Kinase (ERK) Superfamily
By Bruce W. Jarvis and Erik M. Schaefer, Promega Corporation, and
David T. Miller, Department of Molecular Biology and Pharmacology, Washington University
School of Medicine, St. Louis, MO
The Extracellular Signal-Regulated Protein Kinase (ERK) superfamily is the focus of
intensive study due to its widespread involvement in signaling pathways in both normal and
disease states. Promega's Anti-ACTIVETM MAPK, Anti-ACTIVETM
JNK and the soon to be released Anti-ACTIVETM p38 pAbs provide
researchers with a unique and rigorously tested panel of reagents to sort out the
coordinated regulation of the ERK superfamily members. These antibodies can be used for a
variety of non-radioactive applications, including Western blotting and
immunocytochemistry, allowing a more accurate assessment of enzyme activation in response
to a variety of extracellular stimuli.
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