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Part Two: Neurotrophic Factors - Their Role in Development, Trauma and Disease
Ronald Kalil
Department of Ophthalmology and Visual Sciences, and the Center for Neuroscience
University of Wisconsin, Madison, Wisconsin, 53706 USA
and Peter Lipton
Department of Physiology, and the Center for Neuroscience
University of Wisconsin, Madison, Wisconsin, 53706 USA
Neurotrophic factors have been shown to play a critical role in the normal
development of neurons and appear to mediate a protective response to trauma and disease.
In Part Two of this article, we briefly review the bioactivities of neurotrophic factors
in these processes and provide a model for the role of neurotrophic factors in the
response to ischemia and potentially other traumatic neural injuries. In Part One of this
article, which appeared in Promega Notes 50, we provided an overview of
these factors and their signaling pathways.
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