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TFIID: What's in a name?
Resolving the differences between the cloned protein and the natural activity
Ray Bandziulis
Promega Corporation
The cloning of TFIID marked a significant turning point in the research effort to
dissect the initiation of eukaryotic gene expression. Now the experimental goal is to
rebuild the natural TFIID complex from the recombinant protein up. This effort is
uncovering a number of surprises that shift the focus to the remarkable fine-tuning and
custom assembly which may occur at the promoters of individual genes.
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