Targeted Display: Identifying Differentially Expressed mRNAs

Application of a Rapid Method (Targeted Display) for the Identification of Differentially Expressed mRNAs Following NGF-Induced Neuronal Differentiation in PC12 Cells (1999) Mol. Cell. Neurosci. 13, 119.

A.J.H. Brown¹, C. Hutchings¹, J.F. Burke² and L.V. Mayne¹Department of Biochemistry, University of Sussex, and ²Trafford Centre, Falmer, Brighton BN1 9RY, UK

In the following methods application, Brown et al. offer a relatively quick and easy approach to genomic profiling of cell populations. Based upon the technique called “differential display,” Brown et al. propose “targeted display,” a technique that incorporates a modified subset of oligonucleotide primers and applies the technique to the study of differentiation of PC12 cells.

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