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Neutralization of TrkB Tyrosine Kinase Receptor Activity Using BDNF pAb
by Jean G. Toma and David R. Kaplan* (*Corresponding author: mcdv@musica.mcgill.ca) Montreal Neurological Institute 3801
University Street Montreal, Quebec H3A 2B4 Canada
Neurotrophic factors are prime candidates in many studies aimed at understanding the
mechanisms of some human neurodegenerative diseases. We are focusing on the possible role
of brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, with emphasis on the
cellular events following receptor phosphorylation. Herein, we tested the neutralizing
effect of a BDNF antibody (Cat.#
G1641) on BDNF-mediated activation of TrkB, as assessed by receptor
tyrosine phosphorylation.
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