Immunostaining Glial Cells with Promega’s Anti-Human Neurotrophin Antibodies

by Haila Vickland and Jerry Silver Department of Neurosciences, Case Western Reserve University Cleveland, Ohio 44106-4975 USA

The glial cells of the olfactory system are Schwann-like cells that possess unique characteristics. In the living olfactory nerve, the glial cells from which this cell line derives are known to accompany growing and regenerating axons of the olfactory neurons to their targets in the olfactory bulb. Thus, these glial cells may be involved in the capacity of the olfactory nerve to regenerate, and they have shown remarkable ability to encourage neurite outgrowth in vitro. Previous work in the laboratories of Jerry Silver and James W. Jacobberger resulted in the establishment of the NOBEC-1 cell line, a cell line derived from these olfactory bulb glial cells by immortalization with SV40.

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