Save time with an efficient and robust alternative to standard chromatin immunoprecipitation

The HaloCHIP™ System is a novel method designed for the covalent capture of intracellular protein:DNA complexes without the use of antibodies. Proteins of interest are expressed in cells as HaloTag^® fusion proteins, crosslinked to DNA with formaldehyde and then captured on HaloLink™ Resin. After stringent washing the crosslinks are reversed to release purified DNA fragments from the resin for analysis.

 

 

Antibody-free system

No need to make your own or purchase expensive, qualified antibodies.

Obtain results faster

The entire process from crosslinking to DNA release can be accomplished in 24 hours.

Improved signal-to-noise ratio

Covalent binding of the crosslinked protein:DNA complexes to the HaloLink Resin enables stringent washing to remove non-specific DNA and proteins.

Complete protein characterization with one gene construct

Using a vector based on the HaloTag Technology enables downstream applications without having to re-clone into specific vectors.