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As part of an internal validation process of three STR multiplex systems (named STR-1, STR-2 and STR-3 by the RCMP) to be used in forensic identification, we have completed a study of the French Canadian population of Québec. Allele and genotype frequencies for the 10 polymorphic loci in STR-1 (HUMD3S1358, HUMD21S11 and HUMFGA), STR-2 (HUMTHO1, HUMVWA, HUMF13A1 and HUMFES) and STR-3 (Amelogenin, HUMD5S818, HUMD7S820 and HUMD13S317) were determined in French Canadians from the Montreal and Chicoutimi regions (n= 420-586). PCR products were detected by denaturing polyacrylamide gel electrophoresis coupled with fluorescent-based technology on ABD 377 automatic DNA Sequencers. Statistical analysis did not reveal any significant differences between the two populations. We found no evidence of heterogeneity in the French Canadian population for these loci which met Hardy-Weinberg expectations. Little or no evidence was found for association among the 10 loci. Unlike previously reported data on the Chicoutimi population, no founder effect could be detected for any of the loci examined. Furthermore, comparison of allele frequencies in Quebec with other caucasian databases did not reveal any significant variations. Statistical data and allele frequencies will be presented.