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References and Product Citations

By Michele Arduengo
Promega Corporation

The article contains four sections:
"Introduction and The Presenilins",
"Presenilin Roles in Intracellular Trafficking",
"Presenilin Roles in APP Processing"
and "References and Citations"

References

  1. Online Mendelian Inheritance in Man (2000) “#104300, Alzheimer Disease” http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?104300
  2. Sherrington, E et al., (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease. Nature 375,754.
  3. Levy-Lehad, E. et al. (1995) Candidate Gene for the Chromosome 1 Familial Alzheimer’s Disease locus. Science 269, 973.
  4. Yu, G. et al., (2000) Nicastrin modulate presenilin-mediated notch/glp-1 signal transduction and bAPP processing. Nature. 407, 48.
  5. Hardy, J. and Israel, A. (1999) In Search of g-secretase. Nature 398, 466.
  6. L’Hernault, S.W. and Arduengo, P.M. (1992) Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic division. J. Cell Biol. 199, 55.
  7. Levitan, D. and Greenwald, I. (1995) Facilitation of lin-12 mediated signaling by sel-12, a Caenorhabditis elegans S182 Alzheimer’s disease gene. Nature 377, 351.
  8. Li, X. and Greenwald, I. (1997) HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc. Nat. Acad. Sci. USA 94, 12204.
  9. Hong, C. and Koo, E.H. (1997) Isolation and characterization of Drosophila presenilin homolog. NeuroReport 8, 665.
  10. Tanaguchi, T. et al. (1997) Cloning of the cDNA encoding rat presenilin-1. Gene 186, 73.
  11. Tsujimura, A., Yasojima, K. and Hashimoto-Gotoh, T. (1997) Cloning of Xenopus presenilin-a and -b cDNAs and their differential expression in oogenesis and embryogeneis. Biochem. Biophys. Res. Commun. 231, 391.
  12. Li, J. et al., (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 90, 917.
  13. Imafuku, I. et al., (1999) Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J. Cell Biol. 147, 121.
  14. Lah, J.L. and Levey, A.I. (2000) Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments. Molecular and Cellular Neuroscience 16, 111.
  15. Dewji, N.N. and Singer, S.J. (1997) Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc. Natl. Acad. Sci. USA 94, 9926.
  16. Schwarzman, A L. et al. (1999) Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to collagen matrix. Proc. Natl. Acad. Sci. USA. 96, 7932.
  17. Podlisny, M. et al. (1997) Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C- terminal fragments in normal and Alzheimer brain tissue. Neurobiology of Disease 3, 325.
  18. Arduengo, P.M. et al. (1998) The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis. J. Cell Sci. 111, 3645.
  19. Rogaev, E. I. et al. (1995) Familial Alzheimer’s disease in kindreds with missence mutations in a gene on chromosome 1 related to the Alzheimer’s disease type 3 gene. Nature 376, 775.
  20. Lee, M.K. (1996) Expression of Presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J. Neurosci. 16, 7513.
  21. Shen, J. et al. (1997) Skeletal and CNS defects in presenilin-1-deficient mice. Cell 89, 629.
  22. Wong, D.C. (1997) Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm. Nature 387, 288.
  23. Levitan, D. and Greenwald, I. (1998) Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. Development 125, 3599.
  24. Struhl, G. and Greenwald, I. (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398, 522.
  25. Hardy, J. (1997) Amyloid, the presenilins, and Alzheimer’s Disease. Trends   Neurosci. 20, 154.
  26. Scheuner, D. (1996) Secreted amyloid b-protein similar to that in the serial plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease. Nature Med. 2, 866.
  27. Borchelt, D. et al. (1996) Familial Alzheimer’s Disease-linked Presenilin 1 variants elevate Ab1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005.
  28. Duff, K. et al. (1996) Increased amyloid-b42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710.
  29. DeStrooper, B. et al. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387.
  30. DeStrooper, B. et al. (1999) A presenilin-1 dependent g-secretase-like protease mediates release of Notch intracellular domain. Nature 398, 518.
  31. Wolfe S. et al. (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and g-secretase activity. Nature 398, 513.
  32. Li, Y-M. et al. (2000) Photoactivated g-secretase inhibitors directed to the active site covalently label presenilin-1. Nature 405, 89.
  33. Ye, Y. , N. Lukinora, and M.E. Fortini. (1999) Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants. Nature 398, 525.
  34. Katayama, T. et al. (1999) Presenilin-1 mutations down regulate the signaling pathway of the unfolded-protein response. Nat. Cell Biol. 1, 479.
  35. Niwa, M. et al. (1999) A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of mammalian unfolded protein response. Cell 99, 691.
  36. Yu, G. (2000) Mutation of conserved aspartates affect maturation of both aspartate mutant and endogenous presenilin-1 and presenilin-2 complexes. Proc. Natl. Acad. Sci. USA 97, 6138.
  37. Hardy, J et al. (1997) Lancet 42, 737.
  38. Lendon, C. et al. (1997) Hum. Mutat. 10, 186.
  39. Goutte, C. et al. (2000) aph-2 encodes a novel extracellular protein required for GLP-1 mediated signaling. Development 127, 2481.
  40. Sinha, S. et al. (1999) Purification and cloning of amyloid precursor protein b-secretase from human brain. Nature 402, 537.
  41. Lin, X. et al. (2000) Human aspartic proease memapsin 2 cleaves the b-secretase site of b-amyloid precursor protein. Proc. Natl. Acad. Sci. USA 97, 4.
  42. Vassar, et al. (1999) b-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735.

Promega Product Citations

Product Citation Used for
TNT® T7 Coupled Reticulocyte System (Cat.# L4610) Wolfe, S. et al. (1999) Nature 398, 513. in vitro generation of Ab fragment
Terminal Deoxynucleotidyl Transferase (Cat.# M1871) Kovacs, et al. (1996) Nature Medicine 2, 224. Labeling oligonucleotdie probes
fmol® DNA Cycle Sequencing System (Cat.# Q4100) Levy-Lehad, E. et al.  (1995) Science 269, 973. Sequence of RT-PCR products from normal and AD patient samples
Erase-A-Base® System (Cat.# Q5850) Levitan, D. and Greenwald, I. (1995) Nature 377, 973. Used to create a set of nested deletions for sequencing the sel-12 cDNA
TNT® SP6/T7 Coupled Reticulocyte System (Cat.# L5020) Bunnell, W., Pham, H.V., and Glabe, C.G. (1998) J. Biol. Chem. 273, 31947. in vitro transcription/translation from pGEM construct containing transmembrane domain of APP
pGEM®-3Z Vector (Cat.# P2151) ibid Cloning and bacterial expression of transmembrane domain of APP
Wizard® Plus SV Minipreps DNA Purification System
(Cat.# A1330)		 Theuns, J. et al. (2000) Hum. Mol. Gen. 9, 325. DNA preps for sequencing
Dual-Luciferase® Reporter Assay System (Cat.# E1910) ibid Analysis of 5´ region of PS 1 effect on expression in tissue culture cells
pGL-3 ibid Cloning of PS1 5´ region
Riboprobe® Systems (Cat.# P1420, P1430, P1440) Lee, M.K. et al. (1996) J. Neurosci. 16, 7513. Generation of 32P labeled probe from mouse presenilin cDNAs
Apoptosis Detection System, Fluorescein (Cat.# G3250) Hong, C-S. et al. (1999) J. Neurosci. 19, 637. Quantitation of cell death in retinoic acid treated cells
Taq DNA Polymerase (Cat.# M2031) Arduengo, P.M. et al. (1998) J. Cell. Sci. 111, 3645. PCR of DNA from spe-4 animals
pSP64 Poly(A) Vector (Cat.# P1241) Chow, N. et al. (1998) Proc. Natl. Acad. Sci. USA 95, 9620. Subcloning for RNA "spiking" experiment
HindIII Restriction Endonuclease (Cat.# E1841) ibid Subcloning for RNA "spiking" experiment
pCI-neo Mammalian Expression Vector (Cat.# E1841) Imafuku, I. et al. (1999) J. Cell Biol. 147, 121.. Vector for subcloning of PS1 cDNA
TNT® T7/T3-Coupled Reticulocyte Lysate System (Cat.# L5010) ibid Synthesis of labeled PS1 protein
Apoptosis Detection System, Fluorescein (Cat.# G3250) ibid TUNEL analysis of F9 cells tranfected with wildtype and mutant PS1 constructs
pCI-neo Mammalian Expression Vector (Cat.# E1841) Xia, W. et al. (1997) Proc. Natl. Acad. Sci. USA 94, 8208. Subcloning mutant and wildtype PS1 cDNAs

The article contains four sections:
"Introduction and The Presenilins",
"Presenilin Roles in Intracellular Trafficking",
"Presenilin Roles in APP Processing"
and "References and Citations"

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