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Tuesday, November 08, 2016
Betsy Herold, MD
Antibody dependent cell mediated cytotoxicity (ADCC) is an important immune effector mechanism against tumor and virus-infected cells. In recent years, ADCC has emerged as an important protective immune correlate in a number of vaccine studies for HIV and influenza. This webinar will highlight recent studies demonstrating the central role of FcR functions in vaccine-mediated protection against HSV-1 and HSV-2 infection, challenging the existing paradigm that high titer neutralizing antibodies are required.
Tuesday, October 25, 2016
Micheal M. Rosenblatt, PhD
Traditional protocols require digestion times of up to 18 hours, as well as reduction and alkylation prior to digestion. These denaturants often inhibit enzymes and modify proteins, and require removal prior to analysis. What if you could shorten digestion times to ~30 minutes, without denaturants or reductants or alkylating agents?
Tuesday, September 27, 2016
Richard Somberg, PhD
Therapeutic antibodies designed to block or activate immune checkpoint receptors are a powerful new approach to the treatment of cancer and other diseases. However, due to their biologic complexity the development of therapeutic antibodies requires unique functional and analytical tools. Here we present a suite of MOA-based functional bioassays for use in antibody screening, characterization, potency testing and stability studies.
Tuesday, August 23, 2016
Subhanjan Mondal, PhD
Cell Signaling is key to controlling cell health, and one key signaling node is GTPases. Technical options to analyze the biochemical activities of this incredibly important class of proteins are very limited. To support the needs of the research community, we will present various novel ways to analyze GTPase functions.
Tuesday, August 09, 2016
Leta Steffen, PhD
Real-Time PCR (qPCR) is the workhorse of most gene expression analysis. This webinar will provide an overview of basic qPCR principles compared to traditional PCR and common terms used in assay design and analysis.