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Studying MAP Kinase Signaling with a Small-Molecule Inhibitor,
U0126
Simon T.M. Allard, Promega Corporation
To stimulate cells to proliferate, differentiate or undergo apoptosis, extracellular signals need to be relayed to the
nucleus where they alter the pattern of gene expression. One of the main mechanisms for relaying such signals involves a
group of proteins called the mitogen-activated protein kinases (MAPK). These enzymes are proline-directed serine/threonine
kinases that are activated by dual phosphorylation of threonine and tyrosine residues in response to diverse
extracellular stimuli. Small molecules that inhibit MAPKs, such as U0125, are important for understanding cell signaling.
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