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Rat Hepatocyte Culture Physiology Shows Enhanced Cytochrome P450 Activity on a Synthetic Extracellular Matrix
We examined the impact of a new three-dimensional synthetic
matrix on hepatocyte physiology. Hepatocytes were plated on
Corning® labware with Ultra-Web™ and Ultra-Web™ polyamine surfaces and on Becton
Dickinson (BD) BioCoat™ collagen I
microplates. The samples were then challenged for 48 hours with two known
modulators of cytochrome P450, and P450 activity
was measured using the P450-Glo™ Assay. The data show enhanced physiologic
function of primary rat hepatocytes on
microplates coated with the Ultra-Web™ synthetic matrix.
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