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Multiplexed Viability, Cytotoxicity And Apoptosis Assays For
Cell-Based Screening
Andrew Niles, M.S.1, Tracy Worzella, M.S.1,
Michael Scurria, B.S.2, William Daily, Ph.D.2, Laurent
Bernad, Ph.D.2, Pam Guthmiller, B.S.1, Brian McNamara,
Ph.D.1, Kay Rashka, B.S.1, Deborah Lagne, B.S.1,
and Terry L. Riss, Ph.D.1
1Promega Corporation, 2Promega Biosciences, Inc.
Previously, we introduced the MultiTox-Fluor Multiplex
Cytotoxicity Assay technology as a novel means for determining the relative
number of live and dead cells in culture. In this article, we demonstrate that
the assay technology is sufficiently scalable, sensitive and robust to be
multiplexed with other downstream assays to increase the quality of screening
data.
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