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High-Throughput Kinase Screening Using a Universal Luminescent
Kinase Assay
by Said Goueli, Ph.D., Brad Larson, B.A., Kevin Hsiao, M.S.,
Tracy Worzella, M.S., Promega Corporation; Aoife Gallagher, Ph.D., Deerac
Fluidics; and Eric Matthews, M.S., BMG LABTECH
Phosphotransferases represent a major group of cellular enzymes
that use ATP as a substrate and are implicated in a wide variety of cellular
functions. The homogeneous Kinase-Glo® Luminescent Kinase Assay can
monitor the activity of these enzymes, which have become important drug
discovery targets. This non-radioactive assay is robust and easily amenable to
high-throughput screening applications.
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