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Miniaturizing Luminescent P450-Glo™ Assays for HTS
by Tracy Worzella, M.S., Brad Larson, B.A., Jim Cali, Ph.D.,
Promega Corporation; Aoife Gallagher, Ph.D., Deerac Fluidics; and Eric Matthews,
BMG LABTECH
Determining toxicological properties of drug candidates is an
important aspect of the drug discovery process. Using high-precision liquid
handling instrumentation and robust, scalable reagent chemistries, toxicology
assays can be brought closer to the high-throughput screening stages of drug
development. We demonstrate the scalability of in vitro luminescent P450-Glo™
Assays for high-throughput cytochrome P450 activity screening in low-volume 384-
and 1536-well formats.
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