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A Herpes Simplex Virus Type 2 Protein (ICP10 PK) Inhibits Caspase-3 Activation in Hippocampal Neurons
by D. Perkins, M.Sc., E.F.R. Pereira, Ph.D., and L. Aurelian, Ph.D.
University of Maryland School of Medicine
This article describes the use of Promega's CaspACE™ FITC-VAD-FMK In Situ Marker (Cat.# G7461, G7462)
to investigate caspase activation in primary hippocampal cell cultures. The cells were
infected with either wildtype or mutant HSV-2 that contains a deletion of the genetic
information encoding the amino terminal domain of the large subunit of ribonucleotide
reductase.
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