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| 1. |
Chun, H.S., Gibson, G.E., DeGiorgio, L.A., Zhang, H., Kidd, V.J., and Son J.H.
(2001)
Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism
J. Neurochem.
76
,
1010-21
.
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Notes:
A number of neurotoxins linked with Parkinson's Disease induce apoptosis and activate the JNK signaling pathway in the nigral dopaminergic cell line SN4741. Activation of JNK was also monitored in dopaminergic neurons in mouse brain by immunofluorescent double labeling for tyrosine hydroxylase and active (dually phosphorylated) JNK protein. Brain sections were permeabilized with 0.2% Triton® X-100 and stained with a 1:100 dilution of the Anti-ACTIVE® JNK pAb.
(0002453) |
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Products: Anti-ACTIVE® JNK pAb, Rabbit, (pTPpY) |
| 2. |
Takagi, Y., Nozaki, K., Sugino, T., Hattori, I., and Hashimoto, N.
(2000)
Phosphorylation of c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase after transient forebrain ischemia in mice.
Neurosci. Lett.
294
,
117-120
.
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Notes:
The role of JNK and p38 mitogen-activated protein kinase during transient brain ischemia was examined by immunohistochemistry and Western blot analysis. The authors findings indicate that JNK and p38 MAPK pathways may play important roles in neuronal death during brain ischemia. Levels of active JNK and p38 in mouse brain were determined by Western blot analysis and immunohistochemistry using the Anti-ACTIVE® JNK pAb and the Anti-ACTIVE® p38 pAb. For Western blot analysis the antibodies were diluted 1:5000 while immunohistochemical studies were done with dilutions of 1:1000 and 1:400, respectively. Both JNK and p38 were activated following reperfusion of the ischemic tissue.
(0002409) |
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Products: Anti-ACTIVE® JNK pAb, Rabbit, (pTPpY) | Anti-ACTIVE® p38 pAb, Rabbit, (pTGpY) |
| 3. |
Yoneda, T., Imaizumi, K., Maeda, M., Yui, D., Manabe, T., Katayama, T., Sato, N., Gomi, F., Morihara, T., Mori, Y., Miyoshi, K., Hitomi, J., Ugawa, S., Yamada, S., Okabe, M., and Tohyama, M.
(2000)
Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein.
J. Biol. Chem.
275
,
11114-11120
.
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Notes:
The signaling mechanism of Bcl10, an apoptosis-associated gene mutated in mucosa-associated lymphoid tissue lymphomas, was examined. Activation of the JNK signaling pathway in response to overexpression of Bcl10 in 293 cells was monitored by immunoprecipitation with an anti-JNK1 antibody followed by Western blotting with the Anti-ACTIVE® JNKpAb. Immunohistochemical staining of transgenic mice expressing Bcl10 was also performed with the Anti-ACTIVE® JNK pAb. Mouse thymus was fixed in 4% paraformaldehyde, dehydrated, embedded in paraffin, and sectioned (5 µm thick) prior to immunostaining.
(0002384) |
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Products: Anti-ACTIVE® JNK pAb, Rabbit, (pTPpY) |