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| 1. |
McDaid, H.M., Mani, S., Shen, H-J., Muggia, F., Sonnichsen, D., Horwitz, S.B.
(2002)
Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study
Clin. Cancer Res.
8
,
2035-2043
.
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Notes:
The authors investigated the mechansim of action of BMS-247550, a stable, synthetic derivative of epothilone B, in peripheral blood mononuclear cells and in breast tumor cells. Breast tumor cells expressing multidrug resistance were stained for tubulin bundle formation. Cytotoxicity in these biopsied cells also was examined by staining with Promega's Anti-PARP p85 Fragment, pAb.
(0002497) |
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Products: Anti-PARP p85 Fragment pAb | TMB One Solution |
| 2. |
Zhang, H., Cook, J., Nickel, J., Yu, R., Stecker, K., Myers, K., and Dean, N.M.
(2000)
Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis.
Nat. Biotechnol.
18
,
862-867
.
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Notes:
The authors downregulated the Fas ligand in mouse liver to determine the effect on Fas-mediated apoptosis. Apoptosis was monitored in mouse liver tissue by immunohistochemistry with the Anti-PARP p85 Fragment pAb. Cryostat sections (4.0 µm) were fixed in acetone and stained with a 1:100 of the anti-PARP antibody. An anti-rabbit HRP conjugate and DAB substrate was then used to visualize apoptotic cells. Slides were counterstained with hematoxylin.
(0002356) |
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Products: Anti-PARP p85 Fragment pAb |
| 3. |
Schmidt-Supprian, M., Bloch, W., Courtois, G., Addicks, K., Israel, A., Rajewsky, and Pasparakis, M.
(2000)
NEMO/IKKgamma-deficient mice model incontinentia pigmenti.
Mol. Cell
5
,
981-992
.
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Notes:
The Anti-PARP p85 Fragment pAb was used for immunohistochemical analysis of skin sections of wildtype and Nemo +/- mice. Analysis was performed on 5-10µm paraffin sections.
(0000018) |
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Products: Anti-PARP p85 Fragment pAb |