2008 European HaloTag Seminar Tour

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Promega AG

European HaloTag Seminar Tour

Promega AG cordially invites you to participate in our technical seminar on:

HaloTag^® Technology: A Proteomics Tool for Understanding Protein Function in a Biochemical & Cellular Environment.

Dr. Marjeta Urh, Promega Corporation

The presentation will be given in English.

Abstract
The goal of proteomics is not only identification and quantification of proteins, but also to understand their function, localization and interactions. Significant advances in protein analysis technologies especially development of protein arrays have allowed for simultaneous screening of hundreds of proteins.

However, an inherent problem of most methods is detection of nonspecific interactions which makes identifications of the specific interactions a challenge. It is now an accepted practice to use several different methods, including determining protein localization, to verify specificity of the interaction.

To address these needs we have developed a new method which integrates multiple capabilities, including protein labeling and imaging in living cells and immobilization of proteins onto solid support for identification of protein binding partners and protein function.

The technology is a based on a covalent binding of a protein fusion tag (HaloTag) to specific synthetic ligands. The ligands can carry different fluorescent dyes enabling protein labeling or are attached to solid support for protein immobilization. The specific and covalent nature of capture allows efficient washing and removal of nonspecific interactions without the loss of specific interactions. To demonstrate the power of this technology for analysis of protein function we used several different model systems. We will show how using HaloTag enables simultaneous analysis of protein migration and interactions with other proteins and DNA.

LOCATIONS & DATES

Lausanne:
1. April 2008, 14.00h-15.00h
in collaboration with the EPFL Proteomics Core Facility
Lausanne, EPFL

Zürich:
2. April 2008, 9.30h-10.30h
in collaboration with the Functional Genomics Center Zürich
Zürich, Irchel-Campus

Basel:
2. April 2008, 14.00h-15.00h,
Basel, FMI

If you would like to participate, please fill in the form below and submit it to Promega AG.
Please register here until Wednesday, March 27 the latest.

Privacy Notice: Supplying details above gives Promega permission to contact you at each address provided.

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