RNAi Mechanism 
References Archive

References added on May 21, 2004

Schwarz, D. S. et al. (2004) The RNA-Induced Silencing Complex Is a Mg(2+)-Dependent Endonuclease. Curr. Biol. 14, 787-791.

Tijsterman, M. and Plasterk, R. H. (2004) Dicers at RISC; the mechanism of RNAi. Cell. 117, 1-3.

References added on January 14, 2004

Song, J. J. et al. (2003) The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat. Struct. Biol. 10, 1026-1032.

References added on November 25, 2003.

Castillo-Davis, C. and Hartl, D. (2003) Conservation, relocation and duplication in genome evolution. Trends. Genet. 19, 593-597.

Bernstein, E. et al. (2003) Dicer is essential for mouse development. Nat. Genet. 35, 215-217.

Handa, V. et al. (2003) The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer. Nucl. Acids. Res. 31, 6243-6248.

Updated on March 24, 2004

Tahbaz, N. et al. (2004) Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. EMBO Rep. 5, 189-194.

Matzke, M., et al. (2004) Genetic analysis of RNA-mediated transcriptional gene silencing. Biochim. Biophys. Acta. 1677(1-3), 129-41.

Carmell, M., and Hannon, G. (2004) RNase III enzymes and the initiation of gene silencing. Nat. Struct. Mol. Biol. 11(3), 214-8.

Agrawal, N. et al. (2003) RNA Interference: Biology, Mechanism, and Applications. Micro. Mol. Biol. Rev. 67, 657-685.

Updated on October 8, 2003

Hoa, NT. et al. (2003) Characterization of RNA interference in an Anopheles gambiae cell line. Insect. Biochem, Mol. 33, 949-957.

Swaminathan, S. (2003) RNA interference: RISCing chromatin silence. Nat. Cell. Biol. 5, 773.

References added on September 9, 2003

Tschudi, C. et al. (2003) In vivo analysis of the RNA interference mechanism in Trypanosoma brucei. Methods, 30, 304-312.

Haley, B. et al. (2003) In vitro analysis of RNA interference in Drosophila melanogaster. Methods 30, 330-336.

Previous References:

Amarzguioui, M. et al. Tolerance for mutations and chemical modifications in a siRNA Nucl. Acids. Res. 31, 589-595.

Djikeng, A. et al. An siRNA ribonucleprotein is found associated with polyribosomes in Trypanosoma brucei RNA 9, 802-808 (2003).

Doench, J. et al. siRNAs can function as miRNAs Genes & Development 17, 438-442 (2003).

Holen, T. et al. Similar-behaviour of single-stranded and double-stranded siRNA suggests they act through a common RNAi pathway Nucl. Acids. Res. 9, 2401-2407, (2003).

Lichner, Z. et al. Double-stranded RNA-binding proteins could suppress RNA interference-mediated antiviral defences J. Gen. Virol. 84, 975-980 (2003).

Saunders, L. and Barber, G. The dsRNA binding protein family: critical roles, diverse cellular functions, FASEB 17, 961-983 (2003).

Tang, G. et al. A biochemical framework for RNA silencing in plants, Genes & Development  17, 49-63 (2003).

Hannon, G. J. RNA interference. Nature 418, 244-251 (2002).

Hutvagner, G. & Zamore, P. D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060.

McManus, M. T. & Sharp, P. A. Gene silencing in mammals by small interfering RNAs. Nature Rev. Genet. 3, 737-747 (2002). 

Schwarz, D. S., Hutvagner, G., Haley, B. & Zamore, P. D. Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol. Cell 10, 537-548 (2002).

Zamore, P. D. Ancient pathways programmed by small RNAs. Science 296, 1265-1269 (2002).

Zeng, Y. & Cullen, B. R. RNA interference in human cells is restricted to the cytoplasm. RNA 8, 855-860 (2002). 

Nykanen, A., Haley, B. & Zamore, P. D. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 107, 309-321 (2001).

Sharp, P. A. RNA interference -- 2001. Genes Dev. 15, 485-490 (2001).