Applications of Reporter Gene Assays
Next Generation Reporter Assay Technologies–Today!
Genetic reporters can be used to study a wide range of biological areas, from gene expression and control to cell signaling and drug discovery. The use of luciferase as a reporter provides a system that is extremely sensitive, while also very easy to use.
To learn about the basic design of a reporter assay, view this animation:
Introduction to Reporter Gene Assays
For more overview information read: "Luciferase Reporter Assays: Powerful, Adaptable Tools for Cell Biology Research
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New High-Throughput Technology for Screening Transcriptional Regulatory Elements and Gene Networks
Read article...An Optimized System for Studying Transcriptional and Post-Transcriptional Gene Regulation
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Watch an animation explaining how reporter assays work.
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Search promoter analysis and luciferase...Articles
An Optimized System for Studying Transcriptional and Post-Transcriptional Gene Regulation
Read article...microRNA Biosensors: Application for the psiCHECK™-2 Vector
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Search miRNA and luciferase...Articles
Improved Response Ratio for NF-κB Inhibition Analysis Using New Luciferase Reporter Vector pGL4.32[luc2P/NK-κB-RE/Hygro])
Read article...Using Luciferase Assays to Study G-Protein Coupled Receptor Pathways and Screen for GPCR Modulators
Read article...A Small-Molecule Enhancer of Signal Transducer and Activator of Transcription 1 Transcriptional Activity Accentuates the Antiproliferative Effects of IFN-γ in Human Cancer Cell. Lynch, R.A. et al. (2007) Cancer Res. 67, 1254–61.
Read article...PIASy Regulation of STAT5 Activity: Different Reporter Vectors, Different Responses
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Search luciferase and pathway...Articles
Screening Traditional Chinese Medicines Against Estrogen Receptors alpha and beta
Read article...Using Luciferase Reporter Assays to Screen for GPCR Modulators
Read article...Measuring Cell Health and Viability Sequentially by Same-Well Multiplexing Using the GloMax®-Multi Detection System
Read article...Using Luciferase Assays to Study G-Protein Coupled Receptor Pathways and Screen for GPCR Modulators
Read article...Ultrahigh-Throughput Compound Profiling Using Next-Generation Dispensing Technology
Read article...A Small-Molecule Enhancer of Signal Transducer and Activator of Transcription 1 Transcriptional Activity Accentuates the Antiproliferative Effects of IFN-γ in Human Cancer Cells
Lynch, R.A. et al. (2007) Cancer Res. 67, 1254–61.
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Search luciferase and screen...Articles
RNAi Knockdown in Primary Cells: Suppression of Target Gene with psiSTRIKE™ and psiCHECK™ Vectors and amaxa's Nucleofector® Technology
Read article...Using Bioluminescent Reporter Genes to Optimize shRNA Target Sites for RNAi of the bci/abl Gene
Read Article...The Use of Boluminescent Reporter Genes for RNAi Optimization
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Search siRNA and luciferase...Articles
In Vivo Evaluation of Regulatory Sequences by Analysis of Luciferase Expression
Read Article...Non-Invasive Bioluminescent Imaging Improves Understanding of Tumor Biology
Read article...Bioluminescence Imaging of Live Trout for Virus Detection using EnduRen™ Live Cell Substrate
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Search luciferase and imaging...Articles
Next-Generation Assay for Mammalian Protein Interactions: The CheckMate™Flexi® Vector Mammalian Two-Hybrid System
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Search luciferase and checkmate...Articles
Review: David C. Montefiori (2009) Measuring HIV Neutralization in a Luciferase Reporter Gene Assay. HIV Protocols, Second Edition, Vol. 485, V.R. Prasad and G.V. Kalpana, eds.
Read article...Expanding Applications of Bioluminescence Technology: Predictive Bioassays for TNFα Biologicals Potency and Dose-Standardization Studies
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Search luciferase and potency...Technical Resources
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Introduction to Reporter Gene Assays SwitchGear animationArticles
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Gene Expression Reporter AssaysGuides
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