Drug Discovery at Promega
Monitor Compound Integrity with Ease
In a recent report, researchers at the NCGC describe use of P450-Glo™ Assays to monitor activity of small molecule library compounds stored at room-temperature in DMSO or DMSO:water. They assayed CYP1A2 & 2D6 isoforms in a quantitative HTS format. The homogeneous P450-Glo assay was faster and more efficient than the traditional LC-MS method, and gave similar results.
Read the paperFeatured Applications
ADP-Glo™: The Gold Standard in Kinase Assays
Profile more kinases in-house
Get unsurpassed sensitivity down to 20nM ADP
Use with up to 1mM ATP
Use with any Kinase:substrate combination
Live-Cell Biosensor Technology for GPCR Studies
The new GloSensor™ cAMP Assay is a 'zero step' assay for studies on cAMP kinetics.
- Ideal for GPCRs that signal through cAMP
- Nonlytic, live-cell assay
- Gives more biologically relevant data directly from living cells
Go to the GloSensor™ Technology page to learn about this exciting new technology.
Cell Viability Assays
The MultiTox Assays allow you to measure relative numbers of live and dead cells in a population of cells.
Cell Viability resources...
Genetic Reporters for Analyte Screening
ONE-Glo™ Luciferase Assay Reagent
- Unequaled, robust performance
- Eliminates many handling inconveniences, especially for HTS
DUB-Glo™ Protease: An Easy Assay for DUB, SENP or NEDP Activity
Homogeneous bioluminescent assay.
Measures activity of deubiquitinating (DUB), deSUMOylating (SENP) and deneddylating (NEDP) proteases.
Read more: DUB-Glo™ Protease Assay.
Contact the Drug Discovery Team
Do you have a screening question or a specific target? Are you in need of a custom substrate? Contact the Drug Discovery Team at Promega.