Drug Discovery at Promega

Monitor Compound Integrity with Ease

In a recent report, researchers at the NCGC describe use of P450-Glo™ Assays to monitor activity of small molecule library compounds stored at room-temperature in DMSO or  DMSO:water. They assayed CYP1A2 & 2D6 isoforms in a quantitative HTS format. The homogeneous P450-Glo assay was faster and more efficient than the traditional LC-MS method, and gave similar results.

Read the paper

Featured Applications

ADP-Glo™: The Gold Standard in Kinase Assays

Profile more kinases in-house

Get unsurpassed sensitivity down to 20nM ADP

Use with up to 1mM ATP

Use with any Kinase:substrate combination

See the scientific poster...

Live-Cell Biosensor Technology for GPCR Studies

The new GloSensor™ cAMP Assay is a 'zero step' assay for studies on cAMP kinetics.

  • Ideal for GPCRs that signal through cAMP
  • Nonlytic, live-cell assay
  • Gives more biologically relevant data directly from living cells

Go to the GloSensor™ Technology page to learn about this exciting new technology.

Cell Viability Assays

The MultiTox Assays allow you to measure relative numbers of live and dead cells in a population of cells.


    Cell Viability resources...

Genetic Reporters for Analyte Screening

ONE-Glo™ Luciferase Assay Reagent

  • Unequaled, robust performance
  • Eliminates many handling inconveniences, especially for HTS
Genetic Reporter resources...

DUB-Glo™ Protease: An Easy Assay for DUB, SENP or NEDP Activity

Homogeneous bioluminescent assay.

Measures activity of deubiquitinating (DUB), deSUMOylating (SENP) and deneddylating (NEDP) proteases.

Read more: DUB-Glo™ Protease Assay.

Contact the Drug Discovery Team

Do you have a screening question or a specific target? Are you in need of a custom substrate? Contact the Drug Discovery Team at Promega.