Drug Discovery at Promega

The New Gold Standard in Kinase Assays

Profile more kinases in house using a single, easy-to-use platform. ADP-Glo™ Kinase Assay delivers unsurpassed sensitivity and can be used with up to 1mM ATP. The assay measures ADP formation, down to 20nM and can be used with any kinase-substrate combination. ADP-Glo™ Assay tolerates a wide range of conditions and can readily replace existing radioactivity-based assay technologies.

See the scientific poster...

Featured Applications

Live-Cell Biosensor Technology for GPCR Studies

The new GloSensor™ cAMP Assay is a 'zero step' assay for studies on cAMP kinetics. The assay is ideal for GPCRs that signal through cAMP. The nonlytic, live-cell assay is the first application of the patent-pending technology, which features a genetically engineered form of firefly luciferase. Get more biologically relevant data directly from living cells.

Go to the GloSensor™ Technology Web page to learn about this exciting new technology.

Cell Viability Assays

The MultiTox Assays allow you to measure relative numbers of live and dead cells in a population of cells.


    Cell Viability resources...

Genetic Reporters for Analyte Screening

ONE-Glo™ Luciferase Assay Reagent provides unequaled, robust performance while eliminating many of the handling inconveniences that may be experienced when using reporter assays, especially in an HTS environment.

Genetic Reporter resources...

Easy Assay for DUB, SENP or NEDP Activity

The DUB-Glo™ Protease Assay is a homogeneous bioluminescent assay that measures the activity of deubiquitinating (DUB), deSUMOylating (SENP) and deneddylating (NEDP) proteases. These proteases reverse the protein modification by ubiquitin and ubiquitin-like proteins and thus are integral components in the complex mechanisms of posttranslational protein regulation in eukaryotes.

Read more about the Dub-Glo™ Protease Assay.

Contact the Drug Discovery Team

Do you have a screening question or a specific target? Are you in need of a custom substrate? Contact the Drug Discovery Team at Promega.