Cell Signaling
View an animation demonstrating events involved with the phosphatidylinositol-3 (PI3) pathway.
Featured Products
Kinase-Glo® Luminescent Kinase Assays
Assay virtually any kinase and distinguish between competitive and noncompetitive inhibitors with the Kinase-Glo® Luminescent Kinase Assays. This ATP-based kinase assay can be used with a variety of kinase and substrate combinations and does not require any labeled components or antibodies.
cAMP-Glo™ Assay
The cAMP-Glo™ Assay is a bioluminescence assay for monitoring changes in intracellular cAMP concentration with high sensitivity and excellent reproducibility. The assay is robust, easy to use and can be formatted to any size of experiment from single tubes to high-density plates.
Learn more...SignaTECT® Protein Kinase Assay System
These assays contain the proprietary SAM2® Biotin Capture Membrane. These streptavidin-coated membranes possess high binding capacity and high specificity characteristics, resulting lower backgrounds and higher signal-to-noise ratios compared to the traditional P81 phosphocellulose assays. The high binding capacity allows use of the SignaTECT® Systems for kinetic studies.
PDE-Glo™ Phosphodiesterase Assay
PDEs have been implicated in a variety of diseases, such as erectile dysfunction, asthma, chronic obstructive pulmonary disease and learning and memory disorders. The availability of selective inhibitors for PDEs has paved the way to investigate their role in cellular and tissue pathologies. This luminescent, high-throughput screening method allows for identification of lead candidates for PDE inhibitors.