Apoptosis
We offer an extensive array of apoptosis assay systems and detection reagents, including luminescent and fluorescent caspase assays and antibodies,
for the measurement of early or late events in apoptosis.
Featured Products
Homogeneous Luminescent Caspase Assays
The Caspase-Glo® Assays monitor toxic effects of compounds at high-throughput capacities, or one sample at a time, in as little as
15 minutes.
Caspase-Glo® 2 Assay... Caspase-Glo® 6 Assay... Caspase-Glo® 3/7 Assay... Caspase-Glo® 8 Assay... Caspase-Glo® 9 Assay...
Homogeneous Fluorescent Caspase-3/7 Assay
The Apo-ONE® Homogeneous Caspase-3/7 Assay is a fast, sensitive, fluorescent apoptosis detection system featuring a homogeneous format.
Learn more...Nonhomogeneous Caspase Assays
The CaspACE™ Assay System, Colorimetric, provides a colorimetric substrate and a cell-permeable inhibitor that allow highly sensitive, quantitative measurement of caspase-3 (DEVDase) protease activity, an early regulatory event in the apoptotic cell death process.
Learn more...The CaspACE™ Assay System, Fluorometric, provides fluorogenic substrates and inhibitors that allow highly sensitive, quantitative measurement of both ICE (Caspase-1) and CPP32 (Caspase-3) protease activities. This assay system may be used with purified enzyme preparations or cell extracts and also can be adapted for use in high throughput systems.
Learn more...In Situ Caspase Assay
CaspACE™ FITC-VAD-FMK In Situ Marker is a fluoroisothiocyanate (FITC) conjugate of the cell-permeable caspase inhibitor VAD-FMK. This structure allows delivery of the inhibitor into the cell where it binds to activated caspase, serving as an in situ marker for apoptosis. The bound marker is localized by fluorescence detection.
Learn more...DeadEnd™ Fluorometric TUNEL System
Ideal for non-radioactive, simple, accurate and rapid detection of apoptotic cells in situ at the single-cell level or in cell suspensions, this system measures the fragmented DNA of apoptotic cells by catalytically incorporating fluorescein-12-dUTP at 3ยด-OH DNA ends, which can then be visualized by fluorescence microscopy or quantitated by flow cytometry. Learn more...DeadEnd™ Colorimetric TUNEL System
Provides simple, accurate and rapid detection of apoptotic cells in situ at the single-cell level. The system measures nuclear DNA fragmentation, an indicator of apoptosis. The system can be used to assay apoptosis in both tissue sections and cultured cells.
Learn more...Caspase Inhibitors
Z-VAD-FMK is a cell-permeant pan caspase inhibitor that irreversibly binds to the catalytic site of caspase proteases, inhibiting induction of apoptosis.
Learn more...Ac-DEVD-CHO is an inhibitor of caspase-3/7 (DEVDase) activity.
Learn more...