Kinase Enzyme Systems

The Kinase Enzyme Systems allow you to easily screen and profile kinase inhibitors. These systems, created in partnership with SignalChem, span the breath of the human kinome. They provide all the optimized components (enzyme, preferred substrate, required cofactors, buffer) that you need to generate a kinase selectivity profile for a compound.

How to Use This Page: Click anywhere in the image below, or on the tabs running along the bottom of the image, to enlarge that branch of the human kinome. Below each tab is a list of currently available Kinase Enzyme Systems (or those coming soon). Click on any enzyme for additional information (such as Applications Note, the Catalog Page, or the NCBI Database entry) for that kinase.

Would you like an even simpler way to profile compounds for kinase selectivity? The Kinase Selectivity Profiling Systems provide a convenient 8-tube strip format that is optimized for fast and simple kinase inhibitor profiling. You can even create your own custom Kinase Selectivity Profiling System using our Custom Kinase Profiling System Tool.

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Kinase Family Map TK Kinase Family TKL Kinase Family STE Kinase Family CMGC Kinase Family CK1 Kinase Family CAMK Kinase Family AGC Kinase Family ATYPICAL Kinase Family

The group abbreviations are as follows: AGC: Containing PKA, PKG, PKC families; CAMK: Calcium/calmodulin-dependent protein kinase; CK1: Casein kinase 1; CMGC: Containing CDK, MAPK, GSK3, CLK families; STE: Homologs of yeast Sterile 7, Sterile 11, Sterile 20 kinases; TK: Tyrosine kinase; TKL: Tyrosine kinase-like. Click on each individual group for more detailed information on the kinase members of that group.

TK Kinase Family
TKL Kinase Family
STE Kinase Family
CMGC Kinase Family
CK1 Kinase Family
CAMK Kinase Family
AGC Kinase Family
OTHER Kinase Family
ATYPICAL Kinase Family