Promega Corporation

Custom Assay Materials Order Form

We have developed a number of specific Toxicity Pathway Reporters and Cell Lines, which are currently available for sale by Quote. Simply mark all those of interest and we will contact you with pricing and delivery time lines.

Note that some materials vary in the selectable marker (e.g., Hygro vs. Puro) or the luc gene portion by a unique PEST sequence (e.g., luc2P vs. luc2CP). Please ensure that you select the desired construct.

Custom materials are developed by the Custom Assay Services team within R&D. Although functionally tested, they are not manufactured under the Promega ISO13485 quality system and are sold “as is” with no warranty either stated or implied.

Vectors for Toxicity Pathway Analysis

	Pathway	Response Element	Name
1	Antioxidant	ARE	pGL4[luc2P/NRF2/Hygro] Vector
2	Control	CMV	pGL4[hRlucP/CMV/Hygro] Vector
3	Control	CMV	pGL4[luc2P/CMV/Hygro] Vector
4	Control	MinP	pGL4[hRlucP/minP/Hygro] Vector
5	DNA damage/p53	p53	pGL4[hRlucP/p53-RE/Hygro] Vector
6	DNA damage/p53	p53	pGL4[luc2P/p53-RE/Hygro] Vector
7	DNA damage/p53	p53	pGL4[luc2P/p53-RE/Puro] Vector
8	ER stress	ATF4	pGL4[luc2P/ATF4-RE/Hygro] Vector
9	ER stress	ATF6	pGL4[luc2P/ATF6-RE/Hygro] Vector
10	Heavy metal stress	MTF1	pGL4[luc2P/MTF1-RE/Hygro] Vector
11	Heat Shock	HSE	pGL4[luc2P/HSE-RE/Hygro] Vector
12	Hypoxia	HIF1	pGL4[hRlucP/HIF1-RE/Hygro] Vector
13	Hypoxia	HIF1	pGL4[luc2P/HIF1-RE/Hygro] Vector
14	MAPK	AP1	pGL4[hRlucP/AP1-RE/Hygro] Vector
15	MAPK	AP1	pGL4[luc2P/AP1-RE/Hygro] Vector
16	Myc	Myc	pGL4[luc2P/Myc/Hygro] Vector
17	Xenobiotic stress	AhR	pGL4[luc2P/XRE-RE/Hygro] Vector
I am interested in a different toxicity pathway reporter vector

Cell Lines for Toxicity Pathway Analysis

	Pathway	Response Element	Cell line background
1	Antioxidant	ARE	HEK293
2	Hypoxia	HIF1	HEK293
3	Hypoxia	HIF1	HEPG2
4	MAPK	AP1	HEK293
5	Ras/MEK-1	SRE	HEK293
6	RhoA (Gα12/13)	SRF	HEK293
I am interested in a different toxicity pathway cell line

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