The Promega @cademy provides a tailored
programme of non-commercial live webinars,
covering a wide range of scientific topics, from
very basic concepts to highly technical research
The title of this webinar is: "Live
and Let Die – How to study Apoptosis".
is a Basic webinar,
these webinars address the basics of specific topics and
technologies, such as genetic reporters or apoptosis.
They are especially useful for students, technicians and
junior scientists in general.
Apoptosis, or programmed cell death, is a normal
component of the development and health of multicellular
organisms. Cells die in response to a variety of stimuli
and during apoptosis they do so in a controlled,
regulated fashion. This makes apoptosis distinct from
another form of cell death called necrosis in which
uncontrolled cell death leads to lysis of cells,
inflammatory responses and, potentially, to serious
health problems. Apoptosis, by contrast, is a process in
which cells play an active role in their own death
(which is why apoptosis is often referred to as cell
Upon receiving specific signals instructing the cells to
undergo apoptosis a number of distinctive changes occur
in the cell. A family of proteins known as caspases are
typically activated in the early stages of apoptosis.
This is followed by distinctive changes in the
morphology of the cells including cell shrinkage and
blebbing, chromatin condensation and fragmentation and
finally phagocytosis of the apoptotic bodies by
In this webinar I will give an overview of the apoptotic
process including stimuli responsible for apoptosis and
the biochemical and morphological changes that occur. I
will discuss the differences between apoptosis and
necrosis and the various methods and techniques that can
be used to detect apoptosis.
This webinar "Live and Let Die – How to study Apoptosis"
was presented by Angus Trowern, Technical Services
Scientist at Promega UK
This webinar was
presented in the past so registration is not possible