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Many cellular processes are orchestrated by kinases and the disruption of the intracellular signaling networks governed by these enzymes leads to many diseases like cancer. Because of the importance of studying kinases and their increasing recognition as validated drug targets, there have been intense research interests in the development of technologies that monitor the activity of these enzymes.

Most methods currently available suffer from a variety of limitations that makes it difficult to address all the needs of kinase basic research, drug screening and profiling with one platform. Towards this goal, a luminescent-based method was developed that measures kinase activity by quantifying the amount of ADP produced during a kinase reaction. This technology is universal and sensitive, uses a broad ATP range, shows high signal-to-background ratios even at low ATP conversion and can address the mode of action of kinase inhibitors and the mechanisms of drug resistance of mutated kinases.

During this webinar, these features and advantages of ADP-Glo technology will be presented and compared with other competing technology and you will be given the possibility to ask questions online.
 


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