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Promega @cademy: Recording/Presentation Request Form

The webinar "Multiplexed In Vitro Viability and Cytotoxicity Methods for Strengthening Predictive Confidence and Improving Mechanistic Content" is a specialist webinar. Specialist webinars address more specialized topics and are useful for PhD students and senior scientists.

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A central tenet of pharmacology is that all compounds have the capacity to induce toxicity due to dosage. These specific toxicity thresholds are inherently linked to cellular exposure period and cell-type susceptibility. Therefore, the practical implementation of any in vitro testing methodology is greatly dependent upon whether the study is designed to identify targeted cytotoxicity (oncology) or potential off-target toxicity (safety). Either way, the traditional experimental paradigm has been to triage data from large primary screening sets, and then examine the �actives� with a battery of secondary assays in parallel. This talk will describe numerous same-well multiplex assay combinations which may obviate parallel assays because they provide immediate orthogonal or complementary measures useful for confirming cytotoxicity or flagging non-conforming points for additional study. For instance, viability and cytotoxicity assays can be added in meaningful combinations with genetic reporter or cytochrome p450 assays, early measures of cellular stress and apoptosis, or assays for specific obligate functional activities. This proposed multiplex paradigm is designed to streamline data acquisition efficiencies by reducing experimental effort, variability and adding mechanistic content.


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